220, 221 is a reference to Mr. Mom.

The boss of Mr Mom’s wife (Martin Mull) visits the home, and Mr Mom (Micheal Keaton) pretends to be a serious handyman (an excuse as to why he’s home all day) He talks about how he will be rewiring his house. The boss says:

“Oh, so are you going to use 220?” (i.e. 220 volt commercial wiring)

Mr Mom says:

“220, 221, whatever it takes…”

My old man still loves that line.